Using Adalimumab to Treat Autoimmune Enteropathy
نویسندگان
چکیده
منابع مشابه
Recalcitrant hypocalcaemia in autoimmune enteropathy.
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome is a monogenic disorder associated with autoimmune destruction of both endocrine and nonendocrine tissues. The classic triad includes candidiasis, hypoparathyroidism, and Addison disease. Up to 25% of patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome also have gastrointestinal manifestati...
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Chronic, unexplained diarrhea in children younger than 3 months old was first characterized as “intractable diarrhea” [1]. The term “protracted diarrhea” was used later to describe infants with frequent and loose stools severe enough to often require parenteral alimentation as nutritional support [2]. The differential diagnosis of enteropathies in infancy and childhood includes inherited epithe...
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Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is useful in the treatment of autoimmune enteropathy. This report also suggests t...
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Adalimumab is a fully humanized anti-tumor necrosis factor alpha monoclonal antibody that was recently granted regulatory approval in the USA for the treatment of moderate to severe Crohn's disease (CD) in children. Like infliximab, the first biologic agent used to treat pediatric CD, regulatory approval was secured many years following approval for adults. The long delay between adult and pedi...
متن کاملFrom autoimmune enteropathy to the IPEX (immune dysfunction, polyendocrinopathy, enteropathy, X-linked) syndrome.
The term autoimmune enteropathy (AIE) was applied to a form of "intractable diarrhoea" with serum gut autoantibodies, characterized by male predominance, early onset, poor response to parenteral nutrition and several autoimmune diseases, mainly type 1 diabetes. In recent years the vague concept of AIE has became more precise thanks to the discovery of its genetic and molecular basis. The FOXP3 ...
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ژورنال
عنوان ژورنال: ACG Case Reports Journal
سال: 2019
ISSN: 2326-3253
DOI: 10.14309/crj.0000000000000265